Benefits and harms of trisodium citrate are listed in this article.The benefits of sodium tricitrate are in the industry, especially in the pharmaceutical and medical industries. Widely used in medicine and food science as an adjuvant or additive. Sodium citrate is widely and specifically used in phosphate-free detergents and cleaners. Since citric acid is a natural compound and a pervasive metabolite of living organisms, it is not surprising that its environmental behavior is highly favorable. In fact, this complex substance is easily biodegradable and weak for aquatic organisms. Sodium trihydrate is the sodium salt of citric acid. It is commonly used in food as a flavor enhancer or preservative. Makes the food taste sour and slightly salty. The benefits and harms of sodium citrate are due to its widespread use.
Sodium tricitrate makes the blood and urine more alkaline or less acidic.
Benefits and harms of trisodium citrate are significantly lowers urinary pH and urinary uric acid excretion and decreases serum uric acid levels in allopurinol-treated individuals. This combination method also effectively improves renal glomerular filtration in a fraction of patients by reducing renal function. Therefore, the use of citrate with allopurinol is useful for the treatment of patients with hyperuricemia.
To better understand how to treat distal renal tubular acidosis (dRTA), the kidneys have many important tasks. One of them is to maintain the balance between acid and base (as opposed to acid) by removing and filtering acids from the blood and through urine. Acidosis occurs when the kidneys are unable to effectively eliminate circulating acids in the blood. The formation of acids in the blood causes an imbalance called “acidosis” or “metabolic acidosis”. Metabolic acidosis can lead to serious health problems and requires immediate medical attention. It can also cause kidney stones, brittle bones, hearing loss, gastrointestinal problems and other medical problems. Not everyone who lives with dRTA experiences the same health problems.
The main goals of treatment are to restore and maintain a natural acid-base balance. While trying to reduce and prevent heart, bone and kidney problems.
The main treatment for dRTA includes alkaline agents that are used to reduce acid spraying in the blood. Alkaline agents can include sodium bicarbonate, potassium bicarbonate, sodium citrate, or potassium citrate.
Sodium bicarbonate plays an important role in the treatment of primary dRTA by helping to reduce blood acidity (pH). As with any medication, you should not take sodium bicarbonate or other medications unless your healthcare provider recommends it. Sodium bicarbonate can be used if sodium bicarbonate is not effective or tolerable.
Potassium bicarbonate or potassium tricitrate can be used when blood potassium levels are low. In some people, urinary calcium levels are high (hypercalciuria) or there is calcium kidney stones. Citrate is converted to bicarbonate in the body and helps to correct acid spraying in the blood. In addition, citrate helps prevent calcium deposits in the kidneys. Sodium (found in sodium bicarbonate, sodium citrate, or other sodium salts) can increase blood and urine calcium levels.
Reducing acid levels by alkaline agents can also help correct imbalances in other electrolytes, such as potassium and phosphorus. Correcting this imbalance may help reduce the risk of bone disease and prevent kidney stones. However, not all patients respond to these treatments in the same way. How treatment works can depend on a number of factors, such as age, stage of general health illness, and other underlying conditions. It also depends on who stays in their treatment plan and takes the medication as prescribed
Sodium tricitrate is an anticoagulant used to collect blood. The final concentration of citrate in blood compounds is highest in plasma products. Normally, the liver rapidly metabolizes transfused citrate. However, during extensive blood transfusions, the capacity of the liver for this transfusion may be excessive. Citrate forms a collection of calcium that reduces ionized calcium and leads to hypocalcemia. Although transient hypocalcemia is usually well tolerated, nerve cell membrane membranes may be affected, causing peripheral or acral paresthesia. Clinical manifestations may include lightheadedness and chills.
Severe hypocalcemia can cause persistent muscle contractions, and if left untreated, can progress to tetany using spasms in multiple muscle groups. It is important to know the early signs of hypocalcemia before starting treatment. Oral administration of calcium in antacids or milk tablets is commonly used for mild citrate toxicity. If symptoms improve, the injection may be stopped, the flow rate may be reduced, or a Ca2 + injection may be given.
Hemodialysis and related treatments for kidney failure include circulating blood outside the body. This extracorporeal circuit, the dialysis machine and its connections to the body, is a non-physiological and coagulation environment.
Anticoagulants, which temporarily inhibit the normal clotting process, are used to counteract the blood clotting of patients during the flow through this circuit to the outside of the body. In the past, heparin was the only anticoagulant used for this purpose, and while it remains the standard anticoagulant, there are other options that may be more appropriate in some situations.
Sodium citrate is one of these alternatives.
Sodium intake is not safe; there are potentially harmful metabolic changes, including acid-base imbalances that can be associated with sodium citrate anticoagulants.
Citrate is an important mediator in the tricarboxylic acid cycle that plays an important role in cellular metabolism. Under normal physiological conditions, the production of ATP through oxidative phosphorylation in mitochondria is an efficient and primary metabolic process in which ATP molecules produce far more than a certain amount of glucose from glycolysis. In contrast, most cancer cells show high levels of glycolysis to produce ATP to meet their energy needs.
Cancer cell metabolism is often referred to as the “Warburg effect”. Cancer cells primarily metabolize glucose through glycolysis and excrete large amounts of macromolecular precursors, including acetyl CoA, to produce fatty acids, non-essential amino acids, and nucleotides. When glycolysis occurs in this way, the cancer cells ferment in a process known as “aerobic glycolysis” even if mitochondrial dysfunction is not present. Therefore, any inhibition of glycolysis may limit or even stop the oncogen proliferation completely, leading to cell death.
ATP deficient cells often undergo apoptosis. Induction of cellular apoptosis by citrate is shown in single-celled organisms as well as cancer cells.
Tip: Tell your doctor if you are pregnant before taking citric acid and trisodium citrate.
Citrate is a safe and effective anticoagulant.
As a food additive, sodium citrate is not bad for you because it is used in small amounts. Special care should be taken when using it as a medicine. It can interact with a variety of medications and can harm those who already have certain conditions, including hyperkalemia.
Sodium citrate, when used as a medicine, treats kidney problems (such as kidney stones) and metabolic acidosis. Simply put, it is the composition of excess acid in body fluids. Sodium citrate is alkaline, so it has the ability to stabilize body systems that are too acidic.
Sodium tricitrate is not completely safe, it interacts with several different types of drugs, especially aluminum drugs. In addition, people with hyperkalemia (too much potassium in the blood) or heart problems should avoid taking sodium tricitrate. In addition, it may cause hypernatremia, which is an excess of sodium in the blood. Symptoms of hypernatremia include drowsiness and weakness. In severe cases, it can even lead to seizures and death. Finally, sodium tricitrate may cause an allergic reaction in some people. As with any medicine, talk to your doctor if you have any other illnesses or are taking any other medicines before taking sodium citrate.
Short-term side effects may include: allergic reaction, dizziness, weakness, restlessness.
If we are familiar with the Benefits and harms of trisodium citrate, we can better use this substance.