There are pharmaceutical raw materials required by the country in our company.Persian YouTube is one of the companies proud to supply the required pharmaceutical raw materials in the country.The company offers a wide range of high purity laboratory chemicals. We supply pharmaceutical raw materials using new technologies.In addition to meeting these needs domestically, we are also engaged in a wide range of pharmaceutical and chemical pharmaceutical raw materials abroad.Today, more than 97% of drug demand in Iran is met by domestic companies and only 3%, in terms of currency value equal to 30%, is imported.Imported drugs are either those whose technical knowledge is not available for production in Iran or are of higher technological methods for production in other countries.Many non-technological, biotechnological and chemical drugs are produced in Iran.Iranian-made medicine is available at a price of one-fiftieth compared to imported drugs.Distributors often communicate with chemical manufacturers, allowing for greater communication in times of supply shortages.The pharmaceutical industry has many limitations and specializations that make this industry on a completely different scale from other industries.The pharmaceutical industry is closely related to and complementary to the medical field, requiring the utmost care in every field from the collection of raw materials to the preparation of the final product for marketing.Some important and interesting facts about the pharmaceutical industry
Just like any other industry, a warehouse is a space to support and assist the manufacturing sector. However, in the case of the pharmaceutical industry, the level of responsibility for the purpose of the products needs more control.
The pharmaceutical company is responsible for designing protocols that guarantee compliance with best practices, while the logistics supplier is responsible for implementing these protocols in the warehouse according to the manufacturer’s needs, the end customer.
Warehouse infrastructure must meet storage needs in terms of volume and distribution criteria. It should have shelves, pallets, cabinets or cabinets that keep a good distance between them.
Raw materials must be stored after making sure the documents have the features and requirements.
Sampling should be done exclusively by quality control personnel and inventories should be checked periodically.
Raw materials must be quarantined until the quality department approves the raw materials. Demand control should then be based on the internal inventory turnover.
All stages of storage must comply with a high level of hygiene of staff and facilities, equipment, devices, materials, containers, and cleaning and disinfection products.
Ensure that there are no raw materials uncoated in stock.
Employees should use personal protective equipment when using cleaning products.
Excess moisture must be removed to prevent microbial contamination.
Storage spaces should be designed and equipped so that containers can be cleaned before storage.
Clearly identify the places where you keep quarantined products.
Materials are categorized by code using an alphabetical system according to their properties and specifications, or according to their turnover.
The storage of temperature-sensitive raw materials should be ventilated to maintain general conditions. Likewise, products must be organized in such a way that they have uniform temperature conditions. The following should be considered to install a cold chain system
Having the capacity to maintain the temperature in the specified range
Avoid placing the product on the floor
Having an alternative energy source to deal with power outages
Have calibrated temperature monitors at least every year
Placing refrigeration equipment in areas where the temperature changes slightly.
In order for any company to provide better services to its customers, it must have a strong supply chain that ensures the availability of resources in terms of time, quantity and location.
When there is a problem in the supply chain, products are unable to meet demand due to a lack of quality raw materials, clinical trials can be stopped and modified, or when FDA inspections raise quality control issues, program delays occur. is created Good manufacturing has always been about attention to detail, and by doing so, CMOs minimize the number of issues that can interfere with project completion. Because the stakes are so high, every CMO must be more careful in selecting and managing their raw material suppliers and outsourced services. The best way to choose a supplier
Do a self-assessment questionnaire. Before selecting suppliers of goods and services, companies should ask each of their suppliers to complete a questionnaire that should provide important information for an initial assessment of supplier suitability and compliance. These questions address the source and quality of raw materials, process efficiency, and evidence of existing quality systems.
It is important to conduct on-site assessments for critical supply sources, conduct on-site quality audits of facilities, operations and supplier quality systems. If an on-site audit is not possible, CMOs can often accept recent evidence of a quality system inspection by a regulatory body such as the FDA, European Medicines Agency (EMA) or others as a substitute for their own on-site audit.
The supplier qualification process must be documented by trained personnel in standard operating procedure reports in order to properly conduct the evaluation. These procedures may include a level system of risk assessment for all suppliers. PersianUtab is a qualified supplier of pharmaceutical raw materials.
In the classification of medicinal substances, they clearly distinguish the substances from each other and also make it possible for us to have a clear line of distinction between the substances. Medicinal raw materials include substrates or elements that are used to produce various types of drugs, such as endocrine disorders drugs, musculoskeletal drugs, anti-infective drugs such as cephalexin, penicillin, ampicillin, safradine, and so on.Auxiliary materials and pharmaceutical raw materials or raw materials used to produce drugs are extracted from various sources. These sources can be natural or artificial. Recently, many raw materials previously obtained from natural sources are produced artificially in part or even as biotechnology. This is because they are artificially economical, safer and much faster to build. Pharmaceutical raw materials are produced using different types of acids, alcohols, esters, phenols, pyridines, etc.
Before starting production, all raw materials must be tested for purity, identity and quality. Depending on the product (tablets and capsules versus biotechnology products), 15-20 to 60 raw materials may be required to produce the product. The amount of raw material testing is determined by the manufacturer.The USP provides monographs for the most common raw materials in the pharmaceutical industry. Often these monographs detail several different analytical techniques. Analysis of moisture, pH, viscosity and Karl Fisher titration is common but sometimes more sophisticated techniques such as HPLC, GC-MS and ICP-MS are required.
Excipients are also called drug carriers. They are carriers and are definitely part of any medicine. It is a well-known fact that the drugs we use contain only a very small fraction of the real drugs that affect bodily changes. The rest is a carrier, which we call pharmaceutically auxiliary substances.
Refers to a Pharmaceutical raw materials required by the country in our company active substance. This is the real part of the drug that is responsible for the effect of the drug. Accuracy is essential for the raw materials used to build the API.Packaging in the pharmaceutical industry must be thin and precise. Raw materials used for pharmaceutical packaging include plastics and polymers, glass, paper, aluminum foil and paper boards and so on. These are used to make most of the packaging used in pharmacies. Because of the variety of products used as raw materials, even packaging is classified separately.
Pharmaceutical raw materials become more expensive.
The sharp rise in the price of raw materials for essential medicines, called Active Drugs (APIs) in pharmaceutical circles, up to 140% in certain cases from the pre-epidemic level, has put a lot of pressure on the industry. The overall increase, due to high imports and supply disruptions from China, averaging nearly 50 percent, has raised doubts about the availability of drugs and could lead to a shortage of drugs, especially those that are key to treating Covid. Leads .
API prices for certain drugs, such as antipyretics, paracetamol, and antibiotics for Covid and metformin, have more than doubled to 139%, 127%, and 124%, respectively.
About 70 percent of the country’s APIs come from China, while dependence on certain life-saving antibiotics such as cephalosporins, azithromycin and penicillin is 90 percent.
Because these drugs are under price control, companies are forced to incur higher costs. Dependence on China for key APIs has been a continuing concern for the industry, affecting critical raw materials for the cardiovascular system, diabetes, antibiotics, anti-allergy drugs and vitamins. But since Covid, prices have risen sharply.