Citric acid is used in medicines as a flavoring and stabilizing agent to mask medicinal flavors.The pharmaceutical industry is one of the most important components of health systems worldwide. It is made up of many public and private organizations that discover, develop, produce and market medicines for human and animal health. The pharmaceutical industry is primarily based on the scientific research and development of drugs that prevent or treat diseases and disorders. Drugs exhibit a wide range of pharmacological activities and toxicological properties. Molecular biologists, pharmacist chemists, and pharmacists improve the benefits of drugs by increasing their potency and specificity.Active drugs and inactive substances combine during pharmaceutical production to form pharmaceutical forms of pharmaceutical products (such as tablets, capsules, liquids, powders, creams and ointments). Drugs can be classified according to their production process and therapeutic benefits.
Citric acid is a weak organic acid commonly used in the food, cosmetics and pharmaceutical industries. The main basis of citric acid, citrate, is a component of the Krebs cycle and occurs naturally during metabolism in all living organisms. It is found naturally in citrus fruits such as lemons and lemons and is used as a natural preservative.Citrate or citric acid is often used to regulate pH, add a sour taste to foods and beverages, and to form salt derivatives of minerals and metals for pharmaceuticals, as in the case of potassium citrate, a dietary supplement. According to the FDA Selection Committee on Foods Generally Known as Safe (GRAS), citrate salts, including citric acid, are generally considered safe when used in natural amounts this is a Applications of citric acid.
The use of an aqueous solution of citric acid and a water-soluble sugar such as lactitol is used as the granulation liquid in the production of tablets.Application of citric acid in pharmaceutical formulation or technologyCitric acid (as a monohydrate or anhydrous substance) is widely used in pharmaceutical formulations and food products, primarily to adjust the pH of solutions as well as to adjust the pH of tablet matrices in intestinal coated formulations for Colon-specific drug delivery has been used experimentally.Citric acid monohydrate is used in the preparation of effervescent granules, while anhydrous citric acid is widely used in the preparation of effervescent tablets. Citric acid has also been shown to improve the stability of spray-dried insulin powder in inhaled formulations.It is also a component of anticoagulant citrate solutions. Therapeutically, citric acid preparations have been used to solve the problem of kidney stones.Citric acid is used in anti-acid and anti-moisture drugs.
Boiling granules are in the form of granular doses of the drug in a dry mixture, which is usually composed of different boils such as sodium bicarbonate, citric acid and tartaric acid. Boiling granules When added to water, acids and bases react to release CO 2, leading to boiling. A combination of tartaric acid and citric acid is used as the boiling base instead of the acid alone because when tartaric acid is used alone, unstable gypsum granules are produced And citric acid alone leads to a sticky mixture that makes it difficult to granulate. Weakly acidic drugs show increased absorption from the gastric environment when formulated in effervescent granular forms. Because most of the medicine remains in the form of a union. The bitter taste of the medicine can be masked by the boil produced when the formula is combined with water. The boiling granules of a weakly acidic drug, metronidazole, were formulated by a melt granulation process using a low-melting bonding compound consisting of a polymer and a hydrophobic melting adhesive such as PEG 4000 and steel alcohol.
Acetaminophen, dichloro-phenazone and carpet isomethane 325 mg / 100 mg / 65 mg
Binosto 70 mg
Buprenorphine hydrochloride (sublingual) 8 mg
Dexmethylphenidate hydrochloride 10 mg
Multivitamin with fluoride (chewing) Multivitamin with fluoride 1 mg
Naproxen 500 mg)
Nutglinide 60 mg
Quetiapine fumarate 100 mg
Temozolomide 140 mg
Mefenamic acid 250 mg
Simvastatin 20 mg