The Method of production of ascorbic acid is given in this article.Ascorbic acid (vitamin C) is an important metabolite for most organisms. In higher organisms, it is essential for various physiological functions and therefore becomes an essential nutrient for animals (such as humans) lacking the biosynthetic pathway. Of the various cellular functions influenced by ascorbate, its role in collagen synthesis is well established. Ascorbic acid is an important function of protecting tissues against harmful oxidative products. This draws attention to this compound and leads to an increase in demand as a food additive.It is of great importance in human nutrition and maintaining health. The current world production of ascorbic acid is estimated at approximately 80,000 tons per year with more than $ 600 million in the global market. It is biologically and chemically synthesized from glucose D.
The production method of ascorbic acid is with two methods of microbial production and fermentation.Ascorbic acid is produced by microorganisms.The two largest producers of ascorbic acid in the world are BASF and Roche. Chinese manufacturers are also a significant source of ascorbic acid in global markets. The synthesis of ascorbic acid L in 1934 by Reichstein and Grussner remains the cornerstone of the commercial production of vitamin C. Almost all industrial ascorbic acid production methods are derived from the Reichstein and Grussner process. This process is a complex process that begins with glucose D and has six main stages.Process issues that need to be improved include enzyme stability and high factor cost. The ultimate prospect of producing ascorbic acid directly from glucose by fermentation is unattainable.Additional bioengineering is required to promote direct fermentation of the glucose pathway to commercialization. Meanwhile, the biodegradation pathway to 2-keto-L-gulonic acid is a good alternative to the conventional Reichstein-Grussner process for making ascorbic acid.
Method of production of ascorbic acid sorbitol was converted to ascorbic acid via 2-keto-l-gulonic acid (2KGA) as a key mediator, using biooxidation with Gluconobacter oxydans and several chemical steps. Today, industrial production processes use additional bioxidation steps with Ketogulonicigenium vulgare as a biocatalyst to convert d-sorbitol to intermediate 2KGA without chemical steps.The enzymes involved are characterized by a wide range of substrates, but the specificity is remarkable. This confusing pattern of properties can be understood from the preferences of these enzymes for some of the isomeric structures that carbohydrate substrates adopt in aqueous solution. Ascorbic acid is commonly synthesized by a variety of known methods, which are generally modifications of the Reichstein process. These are mostly relatively complex chemical processes that use glucose as a raw material.New biotechnological processes that convert glucose to ascorbic acid (vitamin C) in one step will be desirable this is a Benefits and hamrs of Ascorbic acid.
Our bodies need ascorbic acid (vitamin C) to make a substance called collagen, which is needed for the health and repair of skin, bones, teeth and cartilage. We get vitamin C from the food we eat, especially fruits and vegetables. Deficiency of this vitamin in our diet over a period of time can lead to a disease called scurvy. Symptoms of scurvy include bleeding gums, bruising, and joint and muscle pain. It is also said that its deficiency may lead to poor wound healing and problems in fighting infection. Ascorbic acid deficiency can be treated with vitamin C supplements (as ascorbic acid tablets) and by eating foods rich in vitamin C.Fruits rich in ascorbic acid include citrus fruits (such as oranges, grapefruits and lemons), berries (such as blackberries, strawberries, raspberries, blueberries and cranberries), melons, cantaloupes, watermelons and kiwis. Vegetables rich in vitamin C include spinach, green and red peppers, tomatoes, cauliflower, broccoli, Brussels sprouts and potatoes. Try to include some of these fruits and vegetables in the foods you eat regularly.
Ascorbic acid tablets are usually taken once a day. Doses of 25 to 75 mg are sufficient to prevent vitamin C deficiency. You can take the tablets at any time of the day that is easy to remember, both before and after meals. If you are prescribed a higher dose (more than 250 mg), your doctor will recommend that you take this dose in divided doses. Your dose is on the package label to remind you of what your doctor has told you.Do not take more than the recommended or prescribed dose.